Publications

A list of selected recent publications from the University of Oklahoma Natural Products Discovery Group

Note: additional citations can be accessed through PubMed by clicking here

  • Joyner, P. M.; Waters, A. L.; Williams, R. B.; Powell, D. R.; Janakiram, N. B.; Rao, C. V.; Cichewicz, R. H., Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells. J. Nat. Prod., 2011, 74, (4), 857-861. Link to article
  • Joyner, P. M.; Cichewicz, R. H., Bringing natural products into the fold – exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases. Nat. Prod. Rep., 2011, 28, (1), 26-47.  Link to article
  • Joyner, P. M.; Liu, J.; Zhang, Z; Merritt, J.; Qi, F.; Cichewicz, R. H., Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition. Org. Biomol. Chem., 2010, 8, (24), 5486-5489.  Link to article Link to Oklahoma Daily Link to Future Medicinal Chemistry Link to Microbe Magazine
  • Wu, C.; Cichewicz, R; Li, Y; Liu, J.; Roe, B.; Ferretti, J.; Merritt, J.; Qi, F., The genomic island TnSmu2 of Streptococcus mutans encodes a NRPS-PKS gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance. Appl. Environ. Microbiol., 2010, 76, (17), 5815-5826.  Link to article
  • Wang, X. R.; Sena Filho, J. G.; Hoover, A. R.; King, J. B.; Ellis, T. K.; Powell, D. R.; Cichewicz, R. H., Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an Atlantic-Forest-derived Penicillium citreonigrum. J. Nat. Prod. 2010, 73, (5), 942-948.  Link to article
  • Cichewicz, R. H.; Henrikson, J. C.; Wang, X.; Branscum, K. M., Strategies for Accessing Microbial Secondary Metabolites from Silent Biosynthetic Pathways.  In Manual of Industrial Microbiology and Biotechnology (3rd Edition), Baltz, R. H.; Demain, A. L.; Davies, J. E., Eds.  ASM Press: Washington, D.C. 2010; pp 78-95.  Link to publisher
  • Henrikson, J. C.; Gharfeh, M. S.; Easton, A. C.; Easton, J. D.; Glenn, K. L.; Shadfan, M.; Mooberry, S. L.; Hambright, K. D.; Cichewicz, R. H., Reassessing the ichthyotoxin profile of cultured Prymnesium parvum (golden algae) and comparing it to samples collected from recent freshwater bloom and fish kill events in North America. Toxicon 2010, 55, (7), 1396-1404.  Link to article
  • Cichewicz, R. H.; Hambright, K. D., A revised amino group pKa for prymnesins does not provide decisive evidence for a pH-dependent mechanism of Prymnesium parvum's toxicity. Toxicon 2010, 55, (5), 1035-1037.  Link to article
  • Cichewicz, R. H., Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat. Prod. Rep. 2010, 27, (1), 11-22.  Link to article
  • Joyner, P. M.; Matheke, R. M.; Smith, L. M.; Cichewicz, R. H., Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice. J. Proteome Res. 2010, 9, (1), 404-412.  Link to article
  • Sena-Filho, J. G.; Nimmo, S. L.; Xavier, H. S.; Barbosa-Filho, J. M.; Cichewicz, R. H., Phenylethanoid and lignan glycosides from polar extracts of Lantana, a genus of verbenaceous plants widely used in traditional herbal therapies. J. Nat. Prod. 2009, 72, (7), 1344-1347.  Link to article
  • Henrikson, J. C.; Hoover, A. R.; Joyner, P. M.; Cichewicz, R. H., A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger. Org. Biomol. Chem. 2009, 7, (3), 435-438.  Link to article
  • Fisch, K. M.; Gillaspy, A. F.; Gipson, M.; Henrikson, J. C.; Hoover, A. R.; Jackson, L.; Najar, F. Z.; Waegele, H.; Cichewicz, R. H., Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger. J. Ind. Microbiol. Biotechnol. 2009, 36, (9), 1199-1213.  Link to article
  • Williams, R. B.; Henrikson, J. C.; Hoover, A. R.; Lee, A. E.; Cichewicz, R. H., Epigenetic remodeling of the fungal secondary metabolome. Org. Biomol. Chem. 2008, 6, (11), 1895-1897.  Link to article  Link to Highlights in Chemical Science News
  • Williams, R. B.; Gutekunst, W. R.; Joyner, P. M.; Duan, W.; Li, Q.; Ross, C. A.; Williams, T. D.; Cichewicz, R. H., Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity. J. Agric. Food Chem. 2007, 55, (23), 9450-9456.  Link to article
  • Cichewicz, R. H.; Clifford, L. J., Chapter 8 - Native American Medicine. In Traditional Herbal Medicines for Modern Times: Antidiabetic Plants, Soumyanath, A., Ed. Taylor and Francis: London, 2005; pp 169-177.  Link to publisher

Gallery of selected natural products from the University of Oklahoma Natural Products Discovery Group




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